Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mammary glands from virgin or parous Lewis strain rats


ABSTRACT: Independent Lewis rat data used to confirm the finding of the main experiment "Protection against Mammary Tumorigenesis in Multiple Rat Strains (experiment E-TABM-197: https://www.ebi.ac.uk/arrayexpress/experiments/E-TABM-197).

ORGANISM(S): Rattus norvegicus

SUBMITTER: Alexander Stoddard 

PROVIDER: E-TABM-198 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Hormone-induced protection against mammary tumorigenesis is conserved in multiple rat strains and identifies a core gene expression signature induced by pregnancy.

Blakely Collin M CM   Stoddard Alexander J AJ   Belka George K GK   Dugan Katherine D KD   Notarfrancesco Kathleen L KL   Moody Susan E SE   D'Cruz Celina M CM   Chodosh Lewis A LA  

Cancer research 20060601 12


Women who have their first child early in life have a substantially lower lifetime risk of breast cancer. The mechanism for this is unknown. Similar to humans, rats exhibit parity-induced protection against mammary tumorigenesis. To explore the basis for this phenomenon, we identified persistent pregnancy-induced changes in mammary gene expression that are tightly associated with protection against tumorigenesis in multiple inbred rat strains. Four inbred rat strains that exhibit marked differen  ...[more]

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