Metabolomic profiling of twenty metabolites from human tissues in six studies
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): normal
SUBMITTER: Maria Krestyaninova
PROVIDER: E-TABM-290 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects.
Nicholson J K JK O'Flynn M P MP Sadler P J PJ Macleod A F AF Juul S M SM Sönksen P H PH
The Biochemical journal 19840101 2
Resonances for the ketone bodies 3-D-hydroxybutyrate, acetone and acetoacetate are readily detected in serum, plasma and urine samples from fasting and diabetic subjects by 1H n.m.r. spectroscopy at 400 MHz. Besides the simultaneous observation of metabolites, the major advantage of n.m.r. is that little or no pretreatment of samples is required. N.m.r. determinations of 3-D-hydroxybutyrate, acetoacetate, lactate, valine and alanine were compared with determinations made with conventional assays ...[more]
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