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Transcription profiling of Bordetella Bvg phase-locked mutants

ABSTRACT: bvgS phase-locked mutant derivatives of B. bronchiseptica RB50, B. pertussis GMT-1, and B. pertussis Tohama I were grown at 37 degrees C in the absence of modulator and harvested at mid-log phase. Comparison of gene expression profiles identified a set of genes in each strain that were regulated by BvgAS.

INSTRUMENT(S): Scanning hardware

ORGANISM(S): Bordetella bronchiseptica

SUBMITTER: Craig Cummings 

PROVIDER: E-TABM-31 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Species- and strain-specific control of a complex, flexible regulon by Bordetella BvgAS.

Cummings C A CA   Bootsma H J HJ   Relman D A DA   Miller J F JF  

Journal of bacteriology 20060301 5

The Bordetella master virulence regulatory system, BvgAS, controls a spectrum of gene expression states, including the virulent Bvg(+) phase, the avirulent Bvg(-) phase, and at least one Bvg-intermediate (Bvg(i)) phase. We set out to define the species- and strain-specific features of this regulon based on global gene expression profiling. Rather than functioning as a switch, Bvg controls a remarkable continuum of gene expression states, with hundreds of genes maximally expressed in intermediate  ...[more]

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