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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human dermal microvascular endothelial, fibroblast, and glioblastoma cells treated with mycophenolic acid

ABSTRACT: The effect of Mycophenolic acid on primary isolated human dermal microvascular endothelial (HDMVEC) and fibroblast cells as well as human glioblastoma brain tumor cell line (U87).

ORGANISM(S): Homo sapiens

DISEASE(S): glioblastoma

SUBMITTER: Amir Abdollahi

PROVIDER: E-TABM-315 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Molecular mechanisms of the antiangiogenic and antitumor effects of mycophenolic acid.

Domhan Sophie S Muschal Stefan S Schwager Christian C Morath Christian C Wirkner Ute U Ansorge Wilhelm W Maercker Christian C Zeier Martin M Huber Peter E PE Abdollahi Amir A

Molecular cancer therapeutics 20080601 6

The relative risk for the development of malignancies following solid organ transplantation seems to be decreased in patients treated with the immunosuppressive agent mycophenolic acid (MPA). However, the molecular mechanisms of the antineoplastic effects of MPA are not completely understood. Here, we report that human endothelial cells and fibroblasts are highly sensitive to MPA treatment. We found that U87 glioblastoma cells were resistant to MPA treatment in vitro. However, U87 tumor growth w ...[more]

PMID: 18566237

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