Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of third instar larvae of sgf11, nonstop and ada2b Drosophila mutants to investigate development of neuronal connectivity in the visual system

ABSTRACT: SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Vikki Weake

PROVIDER: E-TABM-383 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system.

Weake Vikki M VM Lee Kenneth K KK Guelman Sebastián S Lin Chia-Hui CH Seidel Christopher C Abmayr Susan M SM Workman Jerry L JL

The EMBO journal 20080110 2

Nonstop, which has previously been shown to have homology to ubiquitin proteases, is required for proper termination of axons R1-R6 in the optic lobe of the developing Drosophila eye. Herein, we establish that Nonstop actually functions as an ubiquitin protease to control the levels of ubiquitinated histone H2B in flies. We further establish that Nonstop is the functional homolog of yeast Ubp8, and can substitute for Ubp8 function in yeast cells. In yeast, Ubp8 activity requires Sgf11. We show t ...[more]

PMID: 18188155

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Dataset Information

Transcription profiling of third instar larvae of sgf11, nonstop and ada2b Drosophila mutants to investigate development of neuronal connectivity in the visual system

Publications

SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system.

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