Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

MicroRNA profiling of human chronic lymphocytic leukemia samples to identify whether microRNA profiles are prognostic indicators

ABSTRACT: MicroRNA expression profiles can distinguish normal B cells from malignant B cells in chronic lymphocytic leukemia (CLL). We investigated whether microRNA profiles are associated with known prognostic factors in CLL. We evaluated the microRNA expression profiles of 94 samples of CLL cells for which ZAP-70 expression, mutations in the rearranged IgVH gene, and the time from diagnosis to initial treatment were known. We also investigated the presence of abnormalities in the genomic sequence of 42 microRNA genes.

INSTRUMENT(S): ScanArray 4000XL [PerkinElmer]

ORGANISM(S): Homo sapiens

DISEASE(S): chronic lymphocytic leukemia

SUBMITTER: Flavia Pichiorri 

PROVIDER: E-TABM-41 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

<h4>Background</h4>MicroRNA expression profiles can be used to distinguish normal B cells from malignant B cells in patients with chronic lymphocytic leukemia (CLL). We investigated whether microRNA profiles are associated with known prognostic factors in CLL.<h4>Methods</h4>We evaluated the microRNA expression profiles of 94 samples of CLL cells for which the level of expression of 70-kD zeta-associated protein (ZAP-70), the mutational status of the rearranged immunoglobulin heavy-chain variabl  ...[more]

Similar Datasets

Transcriptomics Transcription profiling of human chronic lymphocytic leukemia miRNA expression validation
2005-10-27 | E-TABM-42 | biostudies-arrayexpress
Transcriptomics MicroRNA profiling of peripheral blood mononuclear cells from CLL patients to identify a signature for specific chromasomal abnormalities (OSU-CCC microRNA array)
2009-10-01 | E-TABM-762 | biostudies-arrayexpress
Transcriptomics MicroRNA profiling of human chronic lymphocytic leukemia cells in reponse to the chromatin modifying agent LBH589
2009-01-28 | E-TABM-628 | biostudies-arrayexpress
Transcriptomics Transcription profiling by array of human chronic lymphocytic leukemia samples
2010-05-10 | E-TABM-973 | biostudies-arrayexpress
Transcriptomics MicroRNA profiling by array of older patients with cytogenetically normal AML with high or low BAALC- and ERG-related gene-expression signatures
2011-09-08 | E-TABM-1071 | biostudies-arrayexpress
Transcriptomics MicroRNA profiling of human cancer samples identifies ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas.
2007-12-01 | E-TABM-184 | biostudies-arrayexpress
Transcriptomics MicroRNA profiling of patients with acute myeloid leukemia to identify microRNA signatures associated with cytogenetics and prognosis
2008-01-10 | E-TABM-405 | biostudies-arrayexpress
Transcriptomics Transcription profiling of human breast cancer cell lines and tissue samples to identify aberrant microRNA expression
2006-01-01 | E-TABM-23 | biostudies-arrayexpress
Transcriptomics MicroRNA profiling of human pancreas to identify expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis
2010-03-11 | E-TABM-664 | biostudies-arrayexpress
Transcriptomics MicroRNA profiling by array of acute myeloid leukemia patient samples for analysis of miR-29b expression
2011-03-16 | E-TABM-944 | biostudies-arrayexpress