Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of spontaneously hypertensive heart failure rats (SHHF) and a reference strain to identify heart failure susceptibility genes


ABSTRACT: We aimed to identify gene variants associated with heart failure by using a rat model of the human disease. We performed invasive cardiac hemodynamic measurements in F2 crosses between spontaneously hypertensive heart failure rats (SHHF) and reference strains. We combined linkage analyses with genome-wide expression profiling .

ORGANISM(S): Rattus norvegicus

SUBMITTER: Oliver Hummel 

PROVIDER: E-TABM-418 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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We aimed to identify genetic variants associated with heart failure by using a rat model of the human disease. We performed invasive cardiac hemodynamic measurements in F2 crosses between spontaneously hypertensive heart failure (SHHF) rats and reference strains. We combined linkage analyses with genome-wide expression profiling and identified Ephx2 as a heart failure susceptibility gene in SHHF rats. Specifically, we found that cis variation at Ephx2 segregated with heart failure and with incre  ...[more]

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