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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of testis from wild type mice and mice with a Sertoli-specific ablation of Dicer

ABSTRACT: Assess the transcriptomic effects of Sertoli-specific ablation of Dicer in mice

ORGANISM(S): Mus musculus

SUBMITTER: Serge Nef

PROVIDER: E-TABM-426 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Sertoli cell Dicer is essential for spermatogenesis in mice.

Papaioannou Marilena D MD Pitetti Jean-Luc JL Ro Seungil S Park Chanjae C Aubry Florence F Schaad Olivier O Vejnar Charles E CE Kühne Francoise F Descombes Patrick P Zdobnov Evgeny M EM McManus Michael T MT Guillou Florian F Harfe Brian D BD Yan Wei W Jégou Bernard B Nef Serge S

Developmental biology 20081128 1

Spermatogenesis requires intact, fully competent Sertoli cells. Here, we investigate the functions of Dicer, an RNaseIII endonuclease required for microRNA and small interfering RNA biogenesis, in mouse Sertoli cell function. We show that selective ablation of Dicer in Sertoli cells leads to infertility due to complete absence of spermatozoa and progressive testicular degeneration. The first morphological alterations appear already at postnatal day 5 and correlate with a severe impairment of the ...[more]

PMID: 19071104

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