Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of testis from wild type mice and mice with a Sertoli-specific ablation of Dicer


ABSTRACT: Assess the transcriptomic effects of Sertoli-specific ablation of Dicer in mice

ORGANISM(S): Mus musculus

SUBMITTER: Serge Nef 

PROVIDER: E-TABM-426 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications


Spermatogenesis requires intact, fully competent Sertoli cells. Here, we investigate the functions of Dicer, an RNaseIII endonuclease required for microRNA and small interfering RNA biogenesis, in mouse Sertoli cell function. We show that selective ablation of Dicer in Sertoli cells leads to infertility due to complete absence of spermatozoa and progressive testicular degeneration. The first morphological alterations appear already at postnatal day 5 and correlate with a severe impairment of the  ...[more]

Similar Datasets

2009-02-25 | E-TABM-544 | biostudies-arrayexpress
2009-06-03 | E-TABM-692 | biostudies-arrayexpress
2011-05-06 | E-MTAB-498 | biostudies-arrayexpress
2011-11-22 | E-MTAB-497 | biostudies-arrayexpress
2011-09-23 | E-MTAB-411 | biostudies-arrayexpress
2012-03-30 | E-MTAB-617 | biostudies-arrayexpress
2010-06-30 | E-TABM-729 | biostudies-arrayexpress
2010-08-18 | E-TABM-769 | biostudies-arrayexpress
2010-06-22 | E-TABM-726 | biostudies-arrayexpress
2009-07-20 | E-TABM-624 | biostudies-arrayexpress