Chromatin immunoprecipitation of p53 in human osteocarcoma cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Simon van Heeringen
PROVIDER: E-TABM-442 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Characterization of genome-wide p53-binding sites upon stress response.
Smeenk Leonie L van Heeringen Simon J SJ Koeppel Max M van Driel Marc A MA Bartels Stefanie J J SJ Akkers Robert C RC Denissov Sergei S Stunnenberg Hendrik G HG Lohrum Marion M
Nucleic acids research 20080512 11
The tumor suppressor p53 is a sequence-specific transcription factor, which regulates the expression of target genes involved in different stress responses. To understand p53's essential transcriptional functions, unbiased analysis of its DNA-binding repertoire is pivotal. In a genome-wide tiling ChIP-on-chip approach, we have identified and characterized 1546 binding sites of p53 upon Actinomycin D treatment. Among those binding sites were known as well as novel p53 target sites, which included ...[more]
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