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Transcription profiling of 5 strains of rat: WKY, spontaneously hypertensive rat (SHR) and 3 reciprocal congenic strains (WconSA, SconSA and SISA)

ABSTRACT: 5 strains of rat, WKY, spontaneously hypertensive rat (SHR) and 3 reciprocal congenic strains (WconSA, SconSA and SISA) were used to generate expression data across the genome using the Affymetrix rat genome chip set comprising the 230 A and 230 B chips. 5 animals from each strain were used. Expression data was determined for 2 ages: 6 week and 24 week with whole kidney RNA.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Richard Dixon

PROVIDER: E-TABM-45 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genetic dissection of a blood pressure quantitative trait locus on rat chromosome 1 and gene expression analysis identifies SPON1 as a novel candidate hypertension gene.

Clemitson Jenny-Rebecca JR Dixon Richard J RJ Haines Steve S Bingham Andrew J AJ Patel Bhakti R BR Hall Laurence L Lo Ming M Sassard Jean J Charchar Fadi J FJ Samani Nilesh J NJ

Circulation research 20070301 7

A region with a major effect on blood pressure (BP) is located on rat chromosome 1. We have previously isolated this region in reciprocal congenic strains (WKY.SHR-Sa and SHR.WKY-Sa) derived from a cross of the spontaneously hypertensive rat (SHR) with the Wistar-Kyoto rat (WKY) and shown that there are 2 distinct BP quantitative trait loci, BP1 and BP2, in this region. Sisa1, a congenic substrain from the SHR.WKY-Sa animals carrying an introgressed segment of 4.3Mb, contains BP1. Here, we repor ...[more]

PMID: 17332427

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