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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human monocytes exposed to lipopolysaccharide or collagen-related peptide to elucidate the transcriptional differences in monocytes responding to either a danger or damage signal

ABSTRACT: stimulation of whole blood using 5 ng/ml lipopolysaccharide (LPS, gram -ve bacterial endotoxin) or 5 ug/ml CRP-18 (collagen-related peptide; GPO-18). Monocytes respond to stimuli differently. This experiment was designed to elucidate the transcriptional differences in monocytes responding to either a danger signal (supplied by LPS) or a damage signal (supplied by CRP-18). CRP-18 is a collagen mimetic and was used to represent collagen exposure at sites of vessel damage. Exposed collagen activates platelts which in turn activate monocytes. The transcriptional differences which ensue are not known yet and were investigated in this work.

ORGANISM(S): Homo sapiens

SUBMITTER: Rosienne Farrugia

PROVIDER: E-TABM-483 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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