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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse primary osteoblastic cells after intermittent of continuous treatment with parathyroid hormone to investigate the role of beta-arrestin2

ABSTRACT: Role of beta-arrestin2 in response to intermittent or continuous parathyroid hormone (PTH) treatment.

ORGANISM(S): Mus musculus

SUBMITTER: Olivier Schaad

PROVIDER: E-TABM-624 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Beta-arrestin2 regulates parathyroid hormone effects on a p38 MAPK and NFkappaB gene expression network in osteoblasts.

Bianchi Estelle N EN Ferrari Serge L SL

Bone 20090625 4

Interaction of the cytoplasmic adaptor molecule beta-arrestin2 with the activated parathyroid hormone (PTH)/PTHrP receptor inhibits G protein mediated signaling and triggers MAPKs signaling. In turn, the effects of both intermittent (i.) and continuous (c.) PTH on bone are altered in beta-arrestin2-deficient (Arrb2(-/-)) mice. To elucidate the expression profile of bone genes responsive to PTH and targeted for regulation by beta-arrestin2, we performed microarray analysis using total RNA from pr ...[more]

PMID: 19560570

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