Dataset Information
Kinase activity profiling shows osteoblast-induced EGFR/ERBB2 signaling in human androgen-sensitive prostate carcinoma cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): osteosarcoma
SUBMITTER: Anne Hansen Ree
PROVIDER: E-TABM-626 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Osteoblast-induced EGFR/ERBB2 signaling in androgen-sensitive prostate carcinoma cells characterized by multiplex kinase activity profiling.
Clinical & experimental metastasis 20090318 5
Bone metastases in prostate cancer are predominantly osteoblastic. To study regulatory mechanisms underlying the establishment of prostate cancer within an osteoblastic microenvironment, human androgen-sensitive prostate carcinoma cells (LNCaP) were treated with culture medium conditioned by human osteoblast-derived sarcoma cells (OHS), and activated signalling pathways in the carcinoma cells were analyzed using microarrays with tyrosine kinase substrates. Network interaction analysis of substra ...[more]
