Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse mammary tumors from animals which have exons 4-7 of the Lkb1 gene deleted


ABSTRACT: Heterozygous germ-line mutations in the LKB1 (STK11) gene cause Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by hamartomatous polyposis of the gastrointestinal tract and an increased risk of colorectal, breast, ovarian, testicular and cervical cancer. To model the effects of LKB1 mutation in mammary tumourigenesis, we have used a conditional gene targeting strategy to generate a mouse in which exons 4-7 of the Lkb1 gene encoding the kinase domain of the protein are deleted specifically in the mammary gland. Mammary gland tumours arise in these mice with a latency of 46-85 weeks and occur in the thoracic or inguinal glands. These mammary gland tumours were characterised as Grade 2 invasive ductal carcinomas or solid papillary carcinomas and resemble those arising in PJS patients. This mouse model of Lkb1 deficiency provides a potentially useful tool to investigate the role of Lkb1 in tumourigenesis and to guide the development of therapeutic approaches

ORGANISM(S): Mus musculus

SUBMITTER: Anita Grigoriadis 

PROVIDER: E-TABM-643 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation.

McCarthy Afshan A   Lord Christopher J CJ   Savage Kay K   Grigoriadis Anita A   Smith Darrin P DP   Weigelt Britta B   Reis-Filho Jorge S JS   Ashworth Alan A  

The Journal of pathology 20091101 3


Heterozygous germline mutations in the LKB1 (STK11) gene cause Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by hamartomatous polyposis of the gastrointestinal tract and an increased risk of colorectal, breast, and other cancers. To model the role of LKB1 mutation in mammary tumourigenesis, we have used a conditional gene targeting strategy to generate a mouse in which exons encoding the kinase domain of Lkb1 were deleted specifically in the mammary gland. Mammary gl  ...[more]

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