Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Anita Grigoriadis
PROVIDER: E-TABM-643 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
The Journal of pathology 20091101 3
Heterozygous germline mutations in the LKB1 (STK11) gene cause Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by hamartomatous polyposis of the gastrointestinal tract and an increased risk of colorectal, breast, and other cancers. To model the role of LKB1 mutation in mammary tumourigenesis, we have used a conditional gene targeting strategy to generate a mouse in which exons encoding the kinase domain of Lkb1 were deleted specifically in the mammary gland. Mammary gl ...[more]