Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

ChIP-seq of Canis familiaris, Gallus gallus, Mus musculus, Homo sapiens, Monodelphis domestica to investigate CEBPA and HNF4a binding in five vertebrates

ABSTRACT: Five-vertebrate ChIP-seq reveals the evolutionary dynamics of trancription factor binding. The SRF files for this experiment can be found in the European Read Archive with study accession number ERP000054. The fastq files can be found in the raw archives and for some assays links to the ENA runs and ENA fastq files are provided.

ORGANISM(S): Canis familiaris

SUBMITTER: Paul Flicek

PROVIDER: E-TABM-722 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding.

Schmidt Dominic D Wilson Michael D MD Ballester Benoit B Schwalie Petra C PC Brown Gordon D GD Marshall Aileen A Kutter Claudia C Watt Stephen S Martinez-Jimenez Celia P CP Mackay Sarah S Talianidis Iannis I Flicek Paul P Odom Duncan T DT

Science (New York, N.Y.) 20100408 5981

Transcription factors (TFs) direct gene expression by binding to DNA regulatory regions. To explore the evolution of gene regulation, we used chromatin immunoprecipitation with high-throughput sequencing (ChIP-seq) to determine experimentally the genome-wide occupancy of two TFs, CCAAT/enhancer-binding protein alpha and hepatocyte nuclear factor 4 alpha, in the livers of five vertebrates. Although each TF displays highly conserved DNA binding preferences, most binding is species-specific, and al ...[more]

PMID: 20378774

Dataset Information

ChIP-seq of Canis familiaris, Gallus gallus, Mus musculus, Homo sapiens, Monodelphis domestica to investigate CEBPA and HNF4a binding in five vertebrates

Publications

Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding.

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