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MicroRNA profiling of human stage I non-small cell lung cancer to quantify microRNA changes associated with disease recurrence

ABSTRACT: Expression of 752 microRNAs in 77 cases of stage I non-small cell lung cancer was examined using a locked nucleic acid microarray to quantify microRNA changes associated with recurrence of the disease after surgical resection.

ORGANISM(S): Homo sapiens

DISEASE(S): bronchioloalveolar carcinoma of lung

SUBMITTER: Santosh Kumar Patnaik

PROVIDER: E-TABM-727 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Evaluation of microRNA expression profiles that may predict recurrence of localized stage I non-small cell lung cancer after surgical resection.

Patnaik Santosh K SK Kannisto Eric E Knudsen Steen S Yendamuri Sai S

Cancer research 20091222 1

Prognostic markers that can predict the relapse of localized non-small cell lung cancer (NSCLC) have yet to be defined. We surveyed expression profiles of microRNA (miRNA) in stage I NSCLC to identify patterns that might predict recurrence after surgical resection of this common deadly cancer. Small RNAs extracted from formalin-fixed and paraffin-embedded tissues were hybridized to locked nucleic acid probes against 752 human miRNAs (representing 82% of the miRNAs in the miRBase 13.0 database) t ...[more]

PMID: 20028859

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