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Transcription profiling of human cell line alveolar type II A549 ingected with HRSVs, time series

ABSTRACT: Microarray technology was used to monitor the level of expression of 9,300 human genes at different time-points after infection of the type II alveolar A549 human cell line with HRSVs.

INSTRUMENT(S): G2565BA DNA microarray scanner [Agilent]

ORGANISM(S): Homo sapiens

SUBMITTER: Luis Lombardia

PROVIDER: E-TABM-79 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Distinct gene subsets are induced at different time points after human respiratory syncytial virus infection of A549 cells.

Martínez Isidoro I Lombardía Luis L García-Barreno Blanca B Domínguez Orlando O Melero José A JA

The Journal of general virology 20070201 Pt 2

cDNA microarray technology was applied to time course analysis of differentially expressed genes in A549 cells following human respiratory syncytial virus (HRSV) infection. Both up- and down-regulation of cellular genes were observed in a time-dependent manner. However, gene up-regulation prevailed over gene down-regulation. Virus infectivity was required as UV-inactivated virus failed to up-regulate/down-regulate those genes. At early times post-infection (0-6 h p.i.) 85 genes were up-regulated ...[more]

PMID: 17251576

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