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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse stromal cell compartment, lineage negative, CD45 negative bone marrow cells from C57B/L6 and B6.SJL (Ly5.1) strains

ABSTRACT: Comparison of gene expression in the stromal cell compartment (Lineage negative, CD45 negative bone marrow cells) of C57B/L6 and B6.SJL (Ly5.1) mice. duplicate samples were analyzed per strain (two biological replicates) and each of the two samples was pooled from 5 mice

ORGANISM(S): Mus musculus

SUBMITTER: Amanda Jo Waterstrat

PROVIDER: E-TABM-829 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Congenic interval of CD45/Ly-5 congenic mice contains multiple genes that may influence hematopoietic stem cell engraftment.

Waterstrat Amanda A Liang Ying Y Swiderski Carol F CF Shelton Brent J BJ Van Zant Gary G

Blood 20091109 2

The B6.SJL-Ptprc(d)Pep3(b)/BoyJ (B6.SJL) congenic mouse strain, a valuable and widely used tool in murine bone marrow transplantation studies, has long been considered equivalent to the parental C57B/L6 (B6) strain with the exception of a small congenic interval on chromosome 1 harboring an alternative CD45/Ly-5 alloantigen (Ly-5.1). In this study we compared functional properties of stem and stromal cells between the strains, and delineated the boundary of the B6.SJL congenic interval. We ident ...[more]

PMID: 19901263

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