Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): normal
SUBMITTER: Stefano Volinia
PROVIDER: E-TABM-866 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Pineau Pascal P Volinia Stefano S McJunkin Katherine K Marchio Agnès A Battiston Carlo C Terris Benoît B Mazzaferro Vincenzo V Lowe Scott W SW Croce Carlo M CM Dejean Anne A
Proceedings of the National Academy of Sciences of the United States of America 20091215 1
MicroRNA (miRNAs) are negative regulators of gene expression and can function as tumor suppressors or oncogenes. Expression patterns of miRNAs and their role in the pathogenesis of hepatocellular carcinoma (HCC) are still poorly understood. We profiled miRNA expression in tissue samples (104 HCC, 90 adjacent cirrhotic livers, 21 normal livers) as well as in 35 HCC cell lines. A set of 12 miRNAs (including miR-21, miR-221/222, miR-34a, miR-519a, miR-93, miR-96, and let-7c) was linked to disease p ...[more]