Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Saccharomyces cerevisiae kinase and phosphatase knockouts

ABSTRACT: All non-essential protein kinases and phosphatases knockouts have been investigated by expression profiling. To investigate redundancy, double mutants are profiled that show a reduced growth according to synthetic genetic interaction data.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Patrick Kemmeren 

PROVIDER: E-TABM-907 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

To understand relationships between phosphorylation-based signaling pathways, we analyzed 150 deletion mutants of protein kinases and phosphatases in S. cerevisiae using DNA microarrays. Downstream changes in gene expression were treated as a phenotypic readout. Double mutants with synthetic genetic interactions were included to investigate genetic buffering relationships such as redundancy. Three types of genetic buffering relationships are identified: mixed epistasis, complete redundancy, and  ...[more]

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