Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Chris Workman
PROVIDER: E-TABM-93 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Workman Christopher T CT Mak H Craig HC McCuine Scott S Tagne Jean-Bosco JB Agarwal Maya M Ozier Owen O Begley Thomas J TJ Samson Leona D LD Ideker Trey T
Science (New York, N.Y.) 20060501 5776
Failure of cells to respond to DNA damage is a primary event associated with mutagenesis and environmental toxicity. To map the transcriptional network controlling the damage response, we measured genomewide binding locations for 30 damage-related transcription factors (TFs) after exposure of yeast to methyl-methanesulfonate (MMS). The resulting 5272 TF-target interactions revealed extensive changes in the pattern of promoter binding and identified damage-specific binding motifs. As systematic f ...[more]