Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse macropages infected with Bacillus anthrasis

ABSTRACT: B.anthracis is able to grow and infect through macrophages, and it is unclear how the bacterium is able to escape the normal killing function of the macrophage. We hope the identification of novel genes will help us to understand the pathogenesis.

ORGANISM(S): Mus musculus

SUBMITTER: Renee Rubio 

PROVIDER: E-TIGR-84 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Murine macrophage transcriptional responses to Bacillus anthracis infection and intoxication.

Bergman Nicholas H NH   Passalacqua Karla D KD   Gaspard Renee R   Shetron-Rama Lynne M LM   Quackenbush John J   Hanna Philip C PC  

Infection and immunity 20050201 2

Interactions between Bacillus anthracis and host macrophages represent critical early events in anthrax pathogenesis, but their details are not clearly understood. Here we report the first genomewide characterization of the transcriptional changes within macrophages infected with B. anthracis and the identification of several hundred host genes that were differentially expressed during this intracellular stage of infection. These loci included both genes that are known to be regulated differenti  ...[more]

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