Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription profiling of mouse kidney and DBA strain among both sexes

ABSTRACT: An individual study of kidney tissue and DBA strain among both sexes

ORGANISM(S): Mus musculus

SUBMITTER: Renee Rubio

PROVIDER: E-TIGR-94 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Transcription profiling of mouse lung tissue among both sexes and three different strains(A/J, C57BL/6, DBA)

Project description:A comparison of lung tissue among both sexes and three different strains(A/J, C57BL/6, DBA) of mouse

2013-01-30 | E-TIGR-96 | biostudies-arrayexpress

Transcription profiling of mouse lung tissue among both sexes and three different strains(A/J, C57BL/6, DBA)

Project description:A comparison of lung tissue among both sexes and three different strains(A/J, C57BL/6, DBA) of mouse

2005-01-01 | E-TIGR-97 | biostudies-arrayexpress

Transcription profiling of mouse kidney tissue among both sexes and three different strains

Project description:A comparison of kidney tissue among both sexes and three different strains of mouse

2005-01-01 | E-TIGR-95 | biostudies-arrayexpress

Expression data from Kidney of DBA/2 Ahsg -/- and WT mice

Project description:DBA/2N Ahsg -/- mice suffer from sever soft tissue calcification. Gene expression in whole kidney of 5-6 week old mice were analyzed, at this stage calcification is not yet macroscopically detectable. Evaluation of the gene expression pattern was performed to provide insights into the mechanisms preceding the formation of mineralized lesions.

2019-12-05 | GSE140951 | GEO

Effect of renal failure and sex on gene expression in mouse strain 129S1/SvlmJ kidneys

Project description:Sex and genetic background are key, but sometimes overlooked factors, that profoundly impact disease susceptibility and presentation in both humans and disease models. We previously showed that deficiency of KLOTHO protein, an important renal regulator of mineral homeostasis and a cofactor for FGF23, causes different phenotypes in 129S1/SvlmJ (129) and C57BL/6J (B6) mouse strains (Kuro-o et al. Mutation of the mouse Klotho gene leads to a syndrome resembling ageing. Nature 390: 45-51, 1997; Salloum JS, Garsetti DE, Rogers MB. Genetic Background Influences the Impact of KLOTHO Deficiency. Physiological Genomics. 52, 512-516 (2020). The 129 strain was more severely affected, with decreased longevity, decreased body weight, and increased amounts of kidney calcification compared to B6 mice. Here we used RNA seq to profile messenger RNAs in kidneys from control (ctrl) healthy and Klotho homozygous deficient strain 129 mice of both sexes. The kidney messenger RNA profiles of control and Klotho homozygous deficient strain B6 mice of both sexes has been submitted separately. Comparing and contrasting the genetic architecture leading to different phenotypes associated with specific inbred mouse strains may reveal previously unrecognized and important metabolic interactions affecting chronic kidney disease. Both sex and kidney status modulated mRNA profiles.

2025-10-01 | GSE308235 | GEO

Effect of renal failure and sex on gene expression in mouse strain C57Bl/6J kidneys

Project description:Sex and genetic background are key, but sometimes overlooked factors, that profoundly impact disease susceptibility and presentation in both humans and disease models. We previously showed that deficiency of KLOTHO protein, an important renal regulator of mineral homeostasis and a cofactor for FGF23, causes different phenotypes in 129S1/SvlmJ (129) and C57BL/6J (B6) mouse strains (Kuro-o et al. Mutation of the mouse Klotho gene leads to a syndrome resembling ageing. Nature 390: 45-51, 1997; Salloum JS, Garsetti DE, Rogers MB. Genetic Background Influences the Impact of KLOTHO Deficiency. Physiological Genomics. 52, 512-516 (2020). The 129 strain was more severely affected, with decreased longevity, decreased body weight, and increased amounts of kidney calcification compared to B6 mice. Here we used RNA seq to profile messenger RNAs in kidneys from control (ctrl) healthy and Klotho homozygous deficient strain B6 mice of both sexes. The kidney messenger RNA profiles of control and Klotho homozygous deficient strain 129 mice of both sexes has been submitted separately. Comparing and contrasting the genetic architecture leading to different phenotypes associated with specific inbred mouse strains may reveal previously unrecognized and important metabolic interactions affecting chronic kidney disease. Both sex and kidney status modulated mRNA profiles.

2025-09-01 | GSE305136 | GEO

Alcohol and fear conditioning produce strain-specific changes in the dorsal hippocampal transcriptome of adolescent C57BL/6J and DBA/2J mice

Project description:Adolescent sensitivity to alcohol is predictive of later alcohol use and is influenced by genetic background. Data from our laboratory suggested that adolescent C57BL/6J and DBA/2J inbred mice differed in susceptibility to dorsal hippocampus-dependent contextual fear learning deficits after acute alcohol exposure. To investigate the biological underpinnings of this strain difference, we examined dorsal hippocampus gene expression via RNA-sequencing after alcohol and/or fear conditioning across male and female C57BL/6J and DBA/2J adolescents. Strains exhibited dramatic differences in dorsal hippocampal gene expression. Specifically, C57BL/6J and DBA/2J strains differed in 3526 transcripts in males and 2675 transcripts in females. We identified pathways likely to be involved in mediating alcohol’s effects on learning, including networks associated with Chrna7 and Fmr1. These findings provide insight into the mechanisms underlying strain differences in alcohol’s effects on learning and suggest that different biological networks are recruited for learning based on genetics, sex, and alcohol exposure.

2024-08-21 | GSE269129 | GEO

Expression data from Kidney of DBA/2 Ahsg -/- and WT mice

Project description:Expression data from Kidney of DBA/2 Ahsg -/- and WT mice

| PRJNA591701 | ENA

Transcriptomic of ileocecal junction of DBA/1 mice with spontaneous arthritis (SpAD)

Project description:The spontaneous arthritis (SpAD) model in the DBA/1 mouse strain resembles the Spondyloarthritis human disease, including the intestinal inflammation characterized by loss of the integrity of the epithelial barrier and increased permeability. The transcriptome characteristics in this mouse model's gut are very scarce. Transcriptome analysis was performed using DNA microarrays of ileocolic junction of DBA/1 strain mice with spontaneous arthritis (SpAD).

2025-08-31 | GSE278297 | GEO

Mus musculus strain:DBA/2N

Project description:Mus musculus strain:DBA/2N Genome sequencing

| PRJNA548912 | ENA