Challenges of Anti-Mesothelin CAR-T-Cell Therapy.
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ABSTRACT:
SUBMITTER: Zhai X
PROVIDER: S-EPMC10000068 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
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Challenges of Anti-Mesothelin CAR-T-Cell Therapy.
Zhai Xuejia X Mao Ling L Wu Min M Liu Jie J Yu Shicang S
Cancers 20230221 5
Chimeric antigen receptor (CAR)-T-cell therapy is a kind of adoptive T-cell therapy (ACT) that has developed rapidly in recent years. Mesothelin (MSLN) is a tumor-associated antigen (TAA) that is highly expressed in various solid tumors and is an important target antigen for the development of new immunotherapies for solid tumors. This article reviews the clinical research status, obstacles, advancements and challenges of anti-MSLN CAR-T-cell therapy. Clinical trials on anti-MSLN CAR-T cells sho ...[more]
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