Development and Experimental Validation of a Novel Prognostic Signature for Gastric Cancer.
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ABSTRACT: Background
Gastric cancer is a malignant tumor with high morbidity and mortality. Therefore, the accurate recognition of prognostic molecular markers is the key to improving treatment efficacy and prognosis.Methods
In this study, we developed a stable and robust signature through a series of processes using machine-learning approaches. This PRGS was further experimentally validated in clinical samples and a gastric cancer cell line.Results
The PRGS is an independent risk factor for overall survival that performs reliably and has a robust utility. Notably, PRGS proteins promote cancer cell proliferation by regulating the cell cycle. Besides, the high-risk group displayed a lower tumor purity, higher immune cell infiltration, and lower oncogenic mutation than the low-PRGS group.Conclusions
This PRGS could be a powerful and robust tool to improve clinical outcomes for individual gastric cancer patients.
SUBMITTER: Liu C
PROVIDER: S-EPMC10000504 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Publications
Development and Experimental Validation of a Novel Prognostic Signature for Gastric Cancer.
Liu Chengcheng C Huo Yuying Y Zhang Yansong Y Yin Fumei F Chen Taoyu T Wang Zhenyi Z Gao Juntao J Jin Peng P Li Xiangyu X Shi Minglei M Zhang Michael Q MQ
Cancers 20230305 5
<h4>Background</h4>Gastric cancer is a malignant tumor with high morbidity and mortality. Therefore, the accurate recognition of prognostic molecular markers is the key to improving treatment efficacy and prognosis.<h4>Methods</h4>In this study, we developed a stable and robust signature through a series of processes using machine-learning approaches. This PRGS was further experimentally validated in clinical samples and a gastric cancer cell line.<h4>Results</h4>The PRGS is an independent risk ...[more]
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