Ontology highlight
ABSTRACT:
SUBMITTER: Mizoguchi T
PROVIDER: S-EPMC10001940 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Mizoguchi Takamasa T Mikami Shohei S Yatou Mari M Kondo Yui Y Omaru Shuhei S Kuwabara Shuhei S Okura Wataru W Noda Syouta S Tenno Takeshi T Hiroaki Hidekazu H Itoh Motoyuki M
International journal of molecular sciences 20230221 5
BMP signaling is critical for many biological processes. Therefore, small molecules that modulate BMP signaling are useful for elucidating the function of BMP signaling and treating BMP signaling-related diseases. Here, we performed a phenotypic screening in zebrafish to examine the in vivo effects of N-substituted-2-amino-benzoic acid analogs NPL1010 and NPL3008 and found that they affect BMP signaling-dependent dorsal-ventral (D-V) patterning and bone formation in zebrafish embryos. Furthermor ...[more]