Ontology highlight
ABSTRACT:
SUBMITTER: Zhong L
PROVIDER: S-EPMC10005765 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Zhong Leilei L Lu Jiawei J Fang Jiankang J Yao Lutian L Yu Wei W Gui Tao T Duffy Michael M Holdreith Nicholas N Bautista Catherine A CA Huang Xiaobin X Bandyopadhyay Shovik S Tan Kai K Chen Chider C Choi Yongwon Y Jiang Jean X JX Yang Shuying S Tong Wei W Dyment Nathanial N Qin Ling L
eLife 20230213
Colony-stimulating factor 1 (Csf1) is an essential growth factor for osteoclast progenitors and an important regulator for bone resorption. It remains elusive which mesenchymal cells synthesize <i>Csf1</i> to stimulate osteoclastogenesis. We recently identified a novel mesenchymal cell population, marrow adipogenic lineage precursors (MALPs), in bone. Compared to other mesenchymal subpopulations, MALPs expressed <i>Csf1</i> at a much higher level and this expression was further increased during ...[more]