Ontology highlight
ABSTRACT:
SUBMITTER: Young E
PROVIDER: S-EPMC10009830 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Young Ellen E Yount Boyd B Pantoja Petraleigh P Henein Sandra S Meganck Rita M RM McBride Jennifer J Munt Jennifer E JE Baric Thomas J TJ Zhu Deanna D Scobey Trevor T Dong Stephanie S Tse Longping V LV Martinez Melween I MI Burgos Armando G AG Graham Rachel L RL White Laura L DeSilva Aravinda A Sariol Carlos A CA Baric Ralph S RS
Nature communications 20230313 1
The four dengue virus serotypes co-circulate globally and cause significant human disease. Dengue vaccine development is challenging because some virus-specific antibodies are protective, while others are implicated in enhanced viral replication and more severe disease. Current dengue tetravalent vaccines contain four live attenuated serotypes formulated to theoretically induce balanced protective immunity. Among the number of vaccine candidates in clinical trials, only Dengvaxia is licensed for ...[more]