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Anti-inflammatory maistemonine-class alkaloids of Stemona japonica.

ABSTRACT: Three hitherto undescribed Stemona alkaloids, named stemajapines A-C (1-3), along with six known alkaloids (4-9), were isolated and identified from the roots of Stemona japonica (Blume) Miq. (Stemonaceae). Their structures were established by the analysis of the mass data, NMR spectra, and computational chemistry. Stemjapines A and B were degraded maistemonines without spiro-lactone ring and skeletal methyl from maistemonine. Concurrence of alkaloids 1 and 2 revealed an undescribed way to form diverse Stemona alkaloids. Bioassay results disclosed the anti-inflammatory natural constituents stemjapines A and C with IC₅₀ values of 19.7 and 13.8 µM, respectively, compared to positive control dexamethasone with 11.7 µM. The findings may point out a new direction of Stemona alkaloids inaddition to its traditional antitussive and insecticide activities.

SUBMITTER: Tan CY

PROVIDER: S-EPMC10011249 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Anti-inflammatory maistemonine-class alkaloids of Stemona japonica.

Tan Cheng-Yong CY Shi Bao-Bao BB Bao Mei-Fen MF Cai Xiang-Hai XH

Natural products and bioprospecting 20230313 1

Three hitherto undescribed Stemona alkaloids, named stemajapines A-C (1-3), along with six known alkaloids (4-9), were isolated and identified from the roots of Stemona japonica (Blume) Miq. (Stemonaceae). Their structures were established by the analysis of the mass data, NMR spectra, and computational chemistry. Stemjapines A and B were degraded maistemonines without spiro-lactone ring and skeletal methyl from maistemonine. Concurrence of alkaloids 1 and 2 revealed an undescribed way to form d ...[more]

PMID: 36913154

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