Dataset Information

Elevated ACE Levels Indicate Diabetic Nephropathy Progression or Companied Retina Impaired.

ABSTRACT:

Objectives

Renin-angiotensin-aldosterone system plays important roles in the development of diabetic nephropathy (DN), and angiotensin converting enzyme (ACE) is the key factor in the process from angiotensin I to angiotensin II, but the variation and roles of serum ACE in DN patients are still unclear.

Methods

Forty-four type 2 diabetes mellitus (T2DM) patients, 75 DN patients, and 36 age-gender-matched healthy volunteers were recruited who attended Xiangya Hospital of Central South University in this case control study. Serum ACE levels and other indexes were tested with commercial kit.

Results

ACE levels in DN were significantly higher than T2DM and controls (F = 9.66, P < 0.001). Serum ACE levels significantly correlated with UmALB (r = 0.3650, P < 0.001), BUN (r = 0.3102, P < 0.001), HbA1c (r = 0.2046, P = 0.0221), ACR (r = 0.4187, P < 0.001), ALB (r = -0.1885, P = 0.0192), and eGFR (r = -0.3955, P < 0.001), and we got an equation that Y = 2.839 + 0.648X₁ + 2.001X₂ + 0.003X₃ - 6.637X₄ +0.416X₅ - 0.134X₆ (Y: ACE; X₁: BUN; X₂: HbA1C; X₃: UmALB; X₄: gender; X₅: ALB; X₆: eGFR, R² = 0.655). When DN patients were divided into advanced-stage and early-stage with or without DR, ACE levels would increase when early-stage DN develops into advanced-stage or companied with DR.

Conclusion

Elevated serum ACE levels may hint DN progression or retina impaired of DN patients.

SUBMITTER: Huang K

PROVIDER: S-EPMC10012155 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Elevated ACE Levels Indicate Diabetic Nephropathy Progression or Companied Retina Impaired.

Huang Kangkang K Liang Yunlai Y Wang Kun K Ma Yating Y Wu Jiahui J Luo Huidan H Yi Bin B

Frontiers in clinical diabetes and healthcare 20220512

<h4>Objectives</h4>Renin-angiotensin-aldosterone system plays important roles in the development of diabetic nephropathy (DN), and angiotensin converting enzyme (ACE) is the key factor in the process from angiotensin I to angiotensin II, but the variation and roles of serum ACE in DN patients are still unclear.<h4>Methods</h4>Forty-four type 2 diabetes mellitus (T2DM) patients, 75 DN patients, and 36 age-gender-matched healthy volunteers were recruited who attended Xiangya Hospital of Central So ...[more]

PMID: 36992775

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Project description:Background and aimLow serum Vitamin D levels have been associated with diabetic nephropathy (DN). Our study aimed to analyse the serum levels of vitamin D in patients suffering from DN and the subsequent changes in serum vitamin D levels as the disease progresses.MethodsPubMed, Embase, SCOPUS and Web of Science were searched using keywords such as '25 hydroxyvitamin D' and 'diabetic nephropathy'. We included observational studies that reported the association between the serum 25 hydroxy vitamin D levels and diabetic nephropathy without restriction to age, gender, and location. R Version 4.1.2 was used to perform the meta-analysis. The continuous outcomes were represented as mean difference (MD) and standard deviation (SD) and dichotomous outcomes as risk ratios (RR) with their 95% confidence interval (CI).ResultsTwenty-three studies were included in our analysis with 7722 patients. Our analysis revealed that vitamin D was significantly lower in diabetic patients with nephropathy than those without nephropathy (MD: -4.32, 95% CI: 7.91-0.74, p-value = .0228). On comparing diabetic patients suffering from normoalbuminuria, microalbuminuria, or macroalbuminuria, we found a significant difference in serum vitamin D levels across different groups. Normoalbuminuria versus microalbuminuria showed a MD of -1.69 (95% CI: -2.28 to -1.10, p-value = .0002), while microalbuminuria versus macroalbuminuria showed a MD of (3.75, 95% CI: 1.43-6.06, p-value = .0058), proving that serum vitamin D levels keep declining as the disease progresses. Notwithstanding, we detected an insignificant association between Grade 4 and Grade 5 DN (MD: 2.29, 95% CI: -2.69-7.28, p-value = .1862).ConclusionSerum Vitamin D levels are lower among DN patients and keep declining as the disease progresses, suggesting its potential benefit as a prognostic marker. However, on reaching the macroalbuminuria stage (Grades 4 and 5), vitamin D is no longer a discriminating factor.

Dataset Information

Elevated ACE Levels Indicate Diabetic Nephropathy Progression or Companied Retina Impaired.

Objectives

Methods

Results

Conclusion

Publications

Elevated ACE Levels Indicate Diabetic Nephropathy Progression or Companied Retina Impaired.

Similar Datasets

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