Ontology highlight
ABSTRACT:
SUBMITTER: Forte M
PROVIDER: S-EPMC10012953 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Forte Maurizio M Marchitti Simona S Di Nonno Flavio F Stanzione Rosita R Schirone Leonardo L Cotugno Maria M Bianchi Franca F Schiavon Sonia S Raffa Salvatore S Ranieri Danilo D Fioriniello Salvatore S Della Ragione Floriana F Torrisi Maria Rosaria MR Carnevale Roberto R Valenti Valentina V Versaci Francesco F Frati Giacomo G Vecchione Carmine C Volpe Massimo M Rubattu Speranza S Sciarretta Sebastiano S
Autophagy 20220906 4
NPPA/atrial natriuretic peptide (natriuretic peptide type A) exerts critical pleiotropic effects in the cardiovascular system, limiting cardiomyocyte hypertrophy and death, reducing cardiac fibrosis and promoting vascular integrity. However, the molecular mechanisms underlying these beneficial effects still need to be clarified. We demonstrated for the first time that macroautophagy/autophagy is involved in the local protective effects of NPPA in cardiomyocytes (CMs), both in vitro and in vivo. ...[more]