Ontology highlight
ABSTRACT: Objective
To assess whether antenatal azithromycin given to pregnant women with vaginal cerclage can reduce preterm birth or not.Materials and methods
We randomized 50 pregnant ladies who underwent cerclage at Ain Shams University Maternity Hospital in group A (receiving 500 mg Azithromycin oral tablets (Zithrokan®, Hikma, Egypt) one tablet orally twice daily for three days in 3 courses at 14th, 24th and 32nd week, plus usual antenatal care) and an identical group B (receiving usual antenatal care). Our primary outcome was gestational age at delivery, and secondary outcomes were birthweight, mode of delivery, and maternal, and perinatal complications. This study was registered on ClinicalTrials.gov with number: NCT04278937.Results
Pregnancy was more prolonged in the Azithromycin group (delivery at 36.8 weeks vs 34.1 weeks; p=0.017). Also, a higher birthweight was observed in the Azithromycin group (2932.6 gm vs 2401.8 gm; p=0.006). No significant difference was found between the two groups as regards to other outcomes (miscarriage, stillbirth, neonatal intensive care unit admission, antepartum hemorrhage, postpartum pyrexia, need for blood transfusion).Conclusion
Adding antenatal azithromycin to women undergoing cerclage prolongs pregnancy and reduces the risk of preterm birth, with a slight increase in birthweight.
SUBMITTER: Ahmed RHM
PROVIDER: S-EPMC10013083 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Ahmed Rania Hassan Mostafa RHM Bayoumy Hassan Awwad HA Ashoush Sherif Ahmed SA Gabr Wessam Kamal Lotfy WKL
Turkish journal of obstetrics and gynecology 20230301 1
<h4>Objective</h4>To assess whether antenatal azithromycin given to pregnant women with vaginal cerclage can reduce preterm birth or not.<h4>Materials and methods</h4>We randomized 50 pregnant ladies who underwent cerclage at Ain Shams University Maternity Hospital in group A (receiving 500 mg Azithromycin oral tablets (Zithrokan<sup>®</sup>, Hikma, Egypt) one tablet orally twice daily for three days in 3 courses at 14<sup>th</sup>, 24<sup>th</sup> and 32<sup>nd</sup> week, plus usual antenatal ...[more]