Ontology highlight
ABSTRACT:
SUBMITTER: Guo H
PROVIDER: S-EPMC10015366 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Guo Hui H Zhang Jiahang J Jiang Zhimin Z Zhu Xiaoxiao X Yang Jing J Mu Rui R Du Ying Y Tian Yong Y Zhu Pingping P Fan Zusen Z
The EMBO journal 20230130 6
Intestinal stem cells (ISCs) at the crypt base are responsible for the regeneration of the intestinal epithelium. However, how ISC self-renewal is regulated still remains unclear. Here we identified a circular RNA, circBtnl1, that is highly expressed in ISCs. Loss of circBtnl1 in mice enhanced ISC self-renewal capacity and epithelial regeneration, without changes in mRNA and protein levels of its parental gene Btnl1. Mechanistically, circBtnl1 and Atf4 mRNA competitively bound the ATP-dependent ...[more]