Dataset Information

Meat Intake Is Associated with a Higher Risk of Ulcerative Colitis in a Large European Prospective Cohort Studyo.

ABSTRACT:

Background and aims

We aimed to investigate the association between protein intake and risk of inflammatory bowel disease [IBD] in the European Prospective Investigation into Cancer and Nutrition.

Methods

A total of 413 593 participants from eight European countries were included. Dietary data were collected at baseline from validated food frequency questionnaires. Dietary data were calibrated to correct errors in measures related to each country-specific questionnaire. Associations between proteins [total, animal, and vegetable] or food sources of animal proteins, and IBD risk were estimated by Cox proportional hazard models.

Results

After a mean follow-up of 16 years, 177 patients with Crohn's disease [CD] and 418 with ulcerative colitis [UC], were identified. There was no association between total protein, animal protein, or vegetable protein intakes and CD or UC risks. Total meat and red meat intakes were associated with UC risk (hazard ratio [HR] for the 4th vs 1st quartile = 1.40, 95% confidence interval [CI] = 0.99-1.98, p-trend = 0.01; and 1.61, 95% CI = 1.10-2.36, p-trend = 0.007, respectively]. There was no association between other food sources of animal protein [processed meat, fish, shellfish, eggs, poultry] and UC. We found no association between food sources of animal proteins and CD risk.

Conclusions

Meat and red meat consumptions are associated with higher risks of UC. These results support dietary counselling of low meat intake in people at high-risk of IBD.

SUBMITTER: Dong C

PROVIDER: S-EPMC10020974 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Publications

Meat Intake Is Associated with a Higher Risk of Ulcerative Colitis in a Large European Prospective Cohort Studyø.

Dong Catherine C Chan Simon S M SSM Jantchou Prevost P Racine Antoine A Oldenburg Bas B Weiderpass Elisabete E Heath Alicia K AK Tong Tammy Y N TYN Tjønneland Anne A Kyrø Cecilie C Bueno de Mesquita Bas B Kaaks Rudolf R Katzke Verena A VA Bergman Manuela M MM Boeing Heiner H Palli Domenico D Masala Giovanna G Tumino Rosario R Sacerdote Carlotta C Colorado-Yohar Sandra M SM Sánchez Maria-Jose MJ Grip Olof O Lindgren Stefan S Luben Robert R Huybrechts Inge I Gunter Marc J MJ Mahamat-Saleh Yahya Y Boutron-Ruault Marie-Christine MC Carbonnel Franck F

Journal of Crohn's & colitis 20220801 8

<h4>Background and aims</h4>We aimed to investigate the association between protein intake and risk of inflammatory bowel disease [IBD] in the European Prospective Investigation into Cancer and Nutrition.<h4>Methods</h4>A total of 413 593 participants from eight European countries were included. Dietary data were collected at baseline from validated food frequency questionnaires. Dietary data were calibrated to correct errors in measures related to each country-specific questionnaire. Associatio ...[more]

PMID: 35396592

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