Ontology highlight
ABSTRACT:
SUBMITTER: Baliova M
PROVIDER: S-EPMC10023026 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Baliova Martina M Jahodova Iveta I Jursky Frantisek F
The protein journal 20230317 4
Small structural E protein of coronaviruses uses its C-terminal PDZ motif to compromise the cellular PDZ interactome. In this work we compared core PDZ interactivity of small (seven amino acids) peptide PDZ motifs, originating from the envelope proteins of recently transmitted coronaviruses SARS-CoV, SARS-CoV2, and MERS-CoV. As the interaction targets we used 23 domains of the largest PDZ proteins MUPP1/MPDZ and PATJ/INAD. Results revealed exceptional affinity and interaction promiscuity of MERS ...[more]