Implantation of engineered human microvasculature to study human infectious diseases in mouse models.
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ABSTRACT:
SUBMITTER: Schonherr-Hellec S
PROVIDER: S-EPMC10024136 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
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Implantation of engineered human microvasculature to study human infectious diseases in mouse models.
Schönherr-Hellec Sophia S Chatzopoulou Eirini E Barnier Jean-Philippe JP Atlas Yoann Y Dupichaud Sébastien S Guilbert Thomas T Dupraz Yves Y Meyer Julie J Chaussain Catherine C Gorin Caroline C Nassif Xavier X Germain Stephane S Muller Laurent L Coureuil Mathieu M
iScience 20230227 4
Animal models for studying human pathogens are crucially lacking. We describe the implantation in mice of engineered human mature microvasculature consisting of endothelial and perivascular cells embedded in collagen hydrogel that allows investigation of pathogen interactions with the endothelium, including <i>in vivo</i> functional studies. Using <i>Neisseria meningitidis</i> as a paradigm of human-restricted infection, we demonstrated the strength and opportunities associated with the use of t ...[more]
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