Ontology highlight
ABSTRACT:
SUBMITTER: Altomare C
PROVIDER: S-EPMC10024709 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Altomare Claudia C Bartolucci Chiara C Sala Luca L Balbi Carolina C Burrello Jacopo J Pietrogiovanna Nicole N Burrello Alessio A Bolis Sara S Panella Stefano S Arici Martina M Krause Rolf R Rocchetti Marcella M Severi Stefano S Barile Lucio L
Communications biology 20230318 1
Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CM) constitute a mixed population of ventricular-, atrial-, nodal-like cells, limiting the reliability for studying chamber-specific disease mechanisms. Previous studies characterised CM phenotype based on action potential (AP) morphology, but the classification criteria were still undefined. Our aim was to use in silico models to develop an automated approach for discriminating the electrophysiological differences between hiPSC ...[more]