Ontology highlight
ABSTRACT:
SUBMITTER: Kolterud A
PROVIDER: S-EPMC10026225 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Kolterud Åsa Å Välimäki Niko N Kuisma Heli H Patomo Joonatan J Ilves Sini T ST Mäkinen Netta N Kaukomaa Jaana J Palin Kimmo K Kaasinen Eevi E Karhu Auli A Pasanen Annukka A Bützow Ralf R Heikinheimo Oskari O Kopp Kallner Helena H Aaltonen Lauri A LA
Human molecular genetics 20230301 7
Precision medicine carries great potential for management of all tumor types. The aim of this retrospective study was to investigate if the two most common genetically distinct uterine fibroid subclasses, driven by aberrations in MED12 and HMGA2 genes, respectively, influence response to treatment with the progesterone receptor modulator ulipristal acetate. Changes in diameter and mutation status were derived for 101 uterine fibroids surgically removed after ulipristal acetate treatment. A signi ...[more]