Ontology highlight
ABSTRACT:
SUBMITTER: Mancebo R
PROVIDER: S-EPMC100268 | biostudies-literature | 2001 May
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20010501 10
The early stages of Drosophila melanogaster development rely extensively on posttranscriptional forms of gene regulation. Deployment of the anterior body patterning morphogen, the Bicoid protein, requires both localization and translational regulation of the maternal bicoid mRNA. Here we provide evidence that the bicoid mRNA is also selectively stabilized during oogenesis. We identify and isolate a protein, BSF, that binds specifically to IV/V RNA, a minimal form of the bicoid mRNA 3' untranslat ...[more]