Ontology highlight
ABSTRACT:
SUBMITTER: Wohns AW
PROVIDER: S-EPMC10027547 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Wohns Anthony Wilder AW Wong Yan Y Jeffery Ben B Akbari Ali A Mallick Swapan S Pinhasi Ron R Patterson Nick N Reich David D Kelleher Jerome J McVean Gil G
Science (New York, N.Y.) 20220225 6583
The sequencing of modern and ancient genomes from around the world has revolutionized our understanding of human history and evolution. However, the problem of how best to characterize ancestral relationships from the totality of human genomic variation remains unsolved. Here, we address this challenge with nonparametric methods that enable us to infer a unified genealogy of modern and ancient humans. This compact representation of multiple datasets explores the challenges of missing and erroneo ...[more]