Ontology highlight
ABSTRACT:
SUBMITTER: Ferri G
PROVIDER: S-EPMC10032529 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Ferri Gabriel G Musikant Daniel D Edreira Martin M MM
PLoS neglected tropical diseases 20230310 3
Trypanosoma cruzi cAMP-mediated invasion has long been described, however, the detailed mechanism of action of the pathway activated by this cyclic nucleotide still remains unknown. We have recently demonstrated a crucial role for Epac in the cAMP-mediated invasion of the host cell. In this work, we gathered evidence indicating that the cAMP/Epac pathway is activated in different cells lines. In accordance, data collected from pull-down experiments designed to identify only the active form of Ra ...[more]