Ontology highlight
ABSTRACT:
SUBMITTER: Pratt KJB
PROVIDER: S-EPMC10032941 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Pratt Karishma J B KJB Shea Jeremy M JM Remesal-Gomez Laura L Bieri Gregor G Smith Lucas K LK Couthouis Julien J Chen Christopher P CP Roy Irena J IJ Gontier Geraldine G Villeda Saul A SA
Cell reports 20221101 6
DNA methylation has emerged as a critical modulator of neuronal plasticity and cognitive function. Notwithstanding, the role of enzymes that demethylate DNA remain to be fully explored. Here, we report that loss of ten-eleven translocation methylcytosine dioxygenase 2 (Tet2), which catalyzes oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), in adult neurons enhances cognitive function. In the adult mouse hippocampus, we detected an enrichment of Tet2 in neurons. Viral-mediat ...[more]