Ontology highlight
ABSTRACT:
SUBMITTER: Dmello C
PROVIDER: S-EPMC10033639 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Dmello Crismita C Zhao Junfei J Chen Li L Gould Andrew A Castro Brandyn B Arrieta Victor A VA Zhang Daniel Y DY Kim Kwang-Soo KS Kanojia Deepak D Zhang Peng P Miska Jason J Yeeravalli Ragini R Habashy Karl K Saganty Ruth R Kang Seong Jae SJ Fares Jawad J Liu Connor C Dunn Gavin G Bartom Elizabeth E Schipma Matthew J MJ Hsu Patrick D PD Alghamri Mahmoud S MS Lesniak Maciej S MS Heimberger Amy B AB Rabadan Raul R Lee-Chang Catalina C Sonabend Adam M AM
Nature communications 20230322 1
Whereas the contribution of tumor microenvironment to the profound immune suppression of glioblastoma (GBM) is clear, tumor-cell intrinsic mechanisms that regulate resistance to CD8 T cell mediated killing are less understood. Kinases are potentially druggable targets that drive tumor progression and might influence immune response. Here, we perform an in vivo CRISPR screen to identify glioma intrinsic kinases that contribute to evasion of tumor cells from CD8 T cell recognition. The screen reve ...[more]