Ontology highlight
ABSTRACT:
SUBMITTER: James RC
PROVIDER: S-EPMC10035509 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Methods in enzymology 20210921
Replication forks encounter numerous challenges as they move through eu- and hetero-chromatin during S phase in mammalian cells. These include a variety of impediments to the unwinding of DNA by the replicative helicase such as alternate DNA structures, transcription complexes and R-loops, DNA-protein complexes, and DNA chemical adducts. Much of our knowledge of these events is based on analysis of markers of the replication stress and DNA Damage Response that follow stalling of replisomes. To e ...[more]