Unknown

Dataset Information

0

Furan Metabolites Are Elevated in Users of Various Tobacco Products and Cannabis.


ABSTRACT: Humans are exposed to furan, a toxicant and possible human carcinogen, through multiple sources including diet and tobacco smoke. The urinary metabolites of furan are derived from the reaction of its toxic metabolite with protein nucleophiles and are biomarkers of exposure and potential harm. An established isotopic dilution liquid-chromatography mass spectrometry method was used to measure these biomarkers in urine from users of e-cigarettes, cannabis, and/or combustible tobacco with/without reduced nicotine levels. Amounts of furan mercapturic acid metabolites were higher in these individuals relative to nonsmokers, indicating that they may be at risk for potential furan-derived toxicities.

SUBMITTER: Vevang KR 

PROVIDER: S-EPMC10035786 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Furan Metabolites Are Elevated in Users of Various Tobacco Products and Cannabis.

Vevang Karin R KR   Zhang Lin L   Grill Alex E AE   Hatsukami Dorothy K DK   Meier Ellen E   Nomura Sarah Oppeneer SO   Robien Kim K   Peterson Lisa A LA  

Chemical research in toxicology 20230130 2


Humans are exposed to furan, a toxicant and possible human carcinogen, through multiple sources including diet and tobacco smoke. The urinary metabolites of furan are derived from the reaction of its toxic metabolite with protein nucleophiles and are biomarkers of exposure and potential harm. An established isotopic dilution liquid-chromatography mass spectrometry method was used to measure these biomarkers in urine from users of e-cigarettes, cannabis, and/or combustible tobacco with/without re  ...[more]

Similar Datasets

| S-EPMC7364847 | biostudies-literature
| S-EPMC8803139 | biostudies-literature
| S-EPMC7930233 | biostudies-literature
| S-EPMC11910409 | biostudies-literature
| S-EPMC10137165 | biostudies-literature
| S-EPMC5473163 | biostudies-literature
| S-EPMC9263615 | biostudies-literature
| S-EPMC4936934 | biostudies-literature
| S-EPMC7297089 | biostudies-literature
| S-EPMC7593365 | biostudies-literature