Ontology highlight
ABSTRACT:
SUBMITTER: Ramzan F
PROVIDER: S-EPMC10038056 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Journal of enzyme inhibition and medicinal chemistry 20231201 1
A series of 20 newly designed (<i>E</i>)-1-(4-sulphamoylphenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2(3H)-ones was synthesised and assessed as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors towards four human isoforms of pharmaceutical interest, that is, hCA I, II, IX and XII. The compounds displayed low to high nanomolar potency against all the isoforms. Introducing strong electron withdrawing groups at the <i>para</i> position of the arylidene ring increased the binding affinity to the enzyme. A ...[more]