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ABSTRACT: Background
Randomized trials have not reported the effects of the early progression of feeding volumes on fluid balance and neurodevelopment among infants born extremely preterm (≤28 weeks).Method
Fluid, electrolyte, and neurodevelopment data of 60 extremely preterm infants randomly assigned to receive either 1 (early feeding group) or 4 days (late feeding group) of trophic feeding volumes at 20-24 mL/kg/day were analyzed.Results
Infants randomized to the early feeding group received less parenteral fluids, generated lower urine volumes, and had less excessive weight loss during the first 14 days after birth. The 7-point difference in cognitive scores and the 0.5 difference in weight-for-age z-scores favoring the early feeding group did not reach statistical significance.Conclusions
In extremely preterm infants, early enteral feeding is associated with less total fluid administration and with less excessive weight loss during the first 2 weeks after birth. These short-term effects could have long-lasting benefits.
SUBMITTER: Durham L
PROVIDER: S-EPMC10038856 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Durham Leandra L Gunawan Emily E Nguyen Kelly K Reeves Audrey A Shukla Vivek V Salas Ariel A AA
Neonatology 20221128 2
<h4>Background</h4>Randomized trials have not reported the effects of the early progression of feeding volumes on fluid balance and neurodevelopment among infants born extremely preterm (≤28 weeks).<h4>Method</h4>Fluid, electrolyte, and neurodevelopment data of 60 extremely preterm infants randomly assigned to receive either 1 (early feeding group) or 4 days (late feeding group) of trophic feeding volumes at 20-24 mL/kg/day were analyzed.<h4>Results</h4>Infants randomized to the early feeding gr ...[more]