Ontology highlight
ABSTRACT:
SUBMITTER: Maksaev G
PROVIDER: S-EPMC10038874 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Maksaev Grigory G Yuan Peng P Nichols Colin G CG
The Journal of general physiology 20230313 5
The Vanilloid thermoTRP (TRPV1-4) subfamily of TRP channels are involved in thermoregulation, osmoregulation, itch and pain perception, (neuro)inflammation and immune response, and tight control of channel activity is required for perception of noxious stimuli and pain. Here we report voltage-dependent modulation of each of human TRPV1, 3, and 4 by the endogenous intracellular polyamine spermine. As in inward rectifier K channels, currents are blocked in a strongly voltage-dependent manner, but, ...[more]