Ontology highlight
ABSTRACT:
SUBMITTER: Orth-He EL
PROVIDER: S-EPMC10042216 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Orth-He Elizabeth L EL Huang Hsin-Che HC Rao Sahana D SD Wang Qinghui Q Chen Qifeng Q O'Mara Claire M CM Chui Ashley J AJ Saoi Michelle M Griswold Andrew R AR Bhattacharjee Abir A Ball Daniel P DP Cross Justin R JR Bachovchin Daniel A DA
Cell reports 20230116 1
NLRP1 and CARD8 are related pattern-recognition receptors (PRRs) that detect intracellular danger signals and form inflammasomes. Both undergo autoproteolysis, generating N-terminal (NT) and C-terminal (CT) fragments. The proteasome-mediated degradation of the NT releases the CT from autoinhibition, but the stimuli that trigger NT degradation have not been fully elucidated. Here, we show that several distinct agents that interfere with protein folding, including aminopeptidase inhibitors, chaper ...[more]