Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases.
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ABSTRACT:
SUBMITTER: Trastoy B
PROVIDER: S-EPMC10042849 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
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Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases.
Trastoy Beatriz B Du Jonathan J JJ Cifuente Javier O JO Rudolph Lorena L García-Alija Mikel M Klontz Erik H EH Deredge Daniel D Sultana Nazneen N Huynh Chau G CG Flowers Maria W MW Li Chao C Sastre Diego E DE Wang Lai-Xi LX Corzana Francisco F Mallagaray Alvaro A Sundberg Eric J EJ Guerin Marcelo E ME
Nature communications 20230327 1
Bacterial pathogens have evolved intricate mechanisms to evade the human immune system, including the production of immunomodulatory enzymes. Streptococcus pyogenes serotypes secrete two multi-modular endo-β-N-acetylglucosaminidases, EndoS and EndoS2, that specifically deglycosylate the conserved N-glycan at Asn297 on IgG Fc, disabling antibody-mediated effector functions. Amongst thousands of known carbohydrate-active enzymes, EndoS and EndoS2 represent just a handful of enzymes that are specif ...[more]
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